FAM124A and TLE5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FAM124A	TLE5
Description		family with sequence similarity 124 member A	TLE family member 5, transcriptional modulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Transcription Factor Complex
	Molecular Function	Protein Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Multicellular Organism Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis
Pathways			Repression of WNT target genes
Drugs
Diseases
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Lipoprotein (a) levels ( 30108283) Metabolite levels ( 23823483) Placental abruption ( 29884306) Rheumatoid arthritis (ACPA-negative) ( 24532677)
Interacting Genes		28 interacting genes: BEND7 CCDC33 CEP70 CGGBP1 DOCK8 FOXP2 IHO1 INO80E KIFC3 LNX1 NKAP PHC2 PRKG1 RAB3IP RBM10 ROCK1 SAXO1 SRPK1 STAC3 THAP1 TLE5 TRIM41 TRIM54 ZBTB44 ZFP64 ZNF165 ZNF250 ZZZ3	165 interacting genes: ABI2 AEN AMH AR ARHGAP32 ATN1 ATP6V0D1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 CABP4 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CFAP206 CIB3 CPSF7 CRACR2A CRX DCUN1D1 DDX6 DGCR6 DIP2A DNMT3L DVL2 EAF1 EAF2 EIF4E2 FAM124A FAM124B FANCG FBF1 FBLN1 FHL3 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GLRX3 GOLGA2 GORASP2 GRAP2 GRB2 GTF2E1 HCN2 HGS HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPLL HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MIA2 MKRN3 MLH1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NLA NTAQ1 NUDT22 OLIG3 OSGIN1 PARVG PHKB POU2F1 PPP1R16A PPP1R16B PRDM1 PRKAA1 PRKAA2 PRKAB2 PRPF31 PRR3 PSMF1 PTRH2 QARS1 RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SMARCB1 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 SUPT5H TBX3 TCF4 TMCC2 TNS2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBE2H UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576
Entrez ID		220108	166
HPRD ID		08704	02556
Ensembl ID		ENSG00000150510	ENSG00000104964
Uniprot IDs		Q86V42	Q08117 Q8WY48
PDB IDs
Enriched GO Terms of Interacting Partners?
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