FBN1 and MYO5C

		FBN1	MYO5C
Description		fibrillin 1	myosin VC
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GO Annotations	Cellular Component	Microfibril Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Cytoplasm Actin Cytoskeleton Myosin Complex Vesicle Extracellular Exosome
	Molecular Function	Integrin Binding Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Protein-containing Complex Binding	Microfilament Motor Activity Motor Activity Calmodulin Binding ATP Binding Actin-dependent ATPase Activity Actin Filament Binding
	Biological Process	Skeletal System Development Metanephros Development Signal Transduction Heart Development Anatomical Structure Morphogenesis Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoclast Differentiation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Osteoclast Development	Actin Filament Organization Vesicle Transport Along Actin Filament
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Ectopia lentis Shprintzen-Goldberg syndrome MASS phenotype Marfan syndrome, including: Marfan syndrome (MFS); Neonatal MFS; Atypically severe MFS; New variant of MFS Weill-Marchesani syndrome, including: Weill-Marchesani syndrome; Weill-Marchesani-like syndrome Geleophysic dysplasia
GWAS		Breast cancer ( 17903305) Central corneal thickness ( 29760442) Height ( 31562340) Hepcidin/ferritin ratio ( 27846281) Hip circumference adjusted for BMI ( 28552196) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Intraocular pressure ( 29617998) Macular thickness ( 30535121) Pulse pressure ( 27841878 28739976 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thoracic aortic aneurysms and dissections ( 21909107)	Glucose homeostasis traits ( 25524916) Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		21 interacting genes: ATXN7 CALR CCPG1 DCN ELN FBLN2 FBN2 HSCB HSPG2 LTBP1 MFAP2 MFAP5 MYO5C MYOC PSMC3 RNF111 SECISBP2L SLBP SPRY2 SPTBN5 VCAN	4 interacting genes: FBN1 IKBKG POT1 RAB8A
Entrez ID		2200	55930
HPRD ID		00618	11380
Ensembl ID		ENSG00000166147	ENSG00000128833
Uniprot IDs		P35555	Q9NQX4
PDB IDs		1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86 5MS9	4L8T 4ZG4 5HMP
Enriched GO Terms of Interacting Partners?
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