EZH2 and BCL11A

Number of citations of the paper that reports this interaction (PubMedID 29263092)
9

Data Source:
BioGRID (pull down)

		EZH2	BCL11A
Description		enhancer of zeste 2 polycomb repressive complex 2 subunit	BAF chromatin remodeling complex subunit BCL11A
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus	Nucleus Nucleoplasm Cytoplasm Postsynaptic Density
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H3-K27 Specific) Primary MiRNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Kinase Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Chromatin Silencing At Telomere Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Histone Methylation Cerebellar Cortex Development Hippocampus Development Response To Estradiol Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Trichostatin A Hepatocyte Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Liver Regeneration Histone H3-K27 Trimethylation Positive Regulation Of Dendrite Development Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Height ( 25282103 31562340) Inflammatory bowel disease ( 28067908) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Acne (severe) ( 24927181 30542056) Attention deficit hyperactivity disorder ( 22012869) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Beta thalassemia/hemoglobin E disease ( 20183929) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epilepsy ( 30531953) F-cell distribution ( 17767159) F-cell distribution in sickle cell anaemia ( 21326311) Face memory ( 31596458) Fetal hemoglobin levels ( 18245381 20018918) Fetal hemoglobin levels in sickle cell anemia ( 25372704) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Hemoglobin A2 levels in sickle cell anemia ( 25042611) Hemoglobin levels ( 26366553) High fetal hemoglobin in sickle cell disease ( 27022141) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Immature fraction of reticulocytes ( 27863252) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 28017375 19862010) Menarche (age at onset) ( 25231870) Methadone dose in opioid dependence ( 28115739) Monocyte early outgrowth colony forming units ( 21493818) Morning person ( 30696823) Number of sexual partners ( 30643258) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Resting heart rate ( 27798624) Risk-taking tendency (4-domain principal component model) ( 30643258) Sickle cell anemia (haemolysis) ( 23406172) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 2 diabetes ( 22885922 24509480 29358691 30297969 20581827 30718926 28869590) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)
Interacting Genes		74 interacting genes: AKT1 ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK2 CDK6 CDKN2B-AS1 CEP63 CRY2 DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H3-4 H3C1 HDAC1 HOTAIR JAK2 KAT2B KDM1A KLHDC2 LATS2 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MUC1 MYCN NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM28 USP7 VAV1 WDR61 WSB2 ZMYND11	26 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 GMCL2 HDAC1 HDAC2 LMO1 MTA1 NCK2 NR2E1 NR2E3 NR2F1 NR2F2 NR2F6 RBBP4 RBBP7 SIN3A SIRT1 SUZ12 UBE2I YME1L1 ZBTB24
Entrez ID		2146	53335
HPRD ID		03342	05949
Ensembl ID		ENSG00000106462	ENSG00000119866
Uniprot IDs		A0A090N8E9 Q15910 S4S3R8	D9YZV9 D9YZW0 Q9H165
PDB IDs		2C6V 4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24	5VTB 6KI6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?