ERG and ADAR

Number of citations of the paper that reports this interaction (PubMedID 24591637)
44

Data Source:
BioGRID (pull down)

		ERG	ADAR
Description		ETS transcription factor ERG	adenosine deaminase RNA specific
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Cellular Response To Virus Negative Regulation Of RNA Interference
Pathways			C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling
Drugs
Diseases		Ewing's sarcoma Prostate cancer	Dyschromatosis symmetrica hereditaria
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Metabolite levels (HVA) ( 23319000) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252) Plateletcrit ( 27863252) Pulse pressure ( 27841878 30578418) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Lung cancer ( 28604730) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		73 interacting genes: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2	5 interacting genes: ERG HDLBP TGM2 UBE2I XPO1
Entrez ID		2078	103
HPRD ID		01298	07528
Ensembl ID		ENSG00000157554	ENSG00000160710
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308	P55265
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP
Enriched GO Terms of Interacting Partners?
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