ERCC2 and GTF2H2C_2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ERCC2	GTF2H2C_2
Description		ERCC excision repair 2, TFIIH core complex helicase subunit	GTF2H2 family member C, copy 2
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Cytoplasm Spindle Cytosol CAK-ERCC2 Complex MMXD Complex	Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nuclear Speck
	Molecular Function	DNA Helicase Activity Damaged DNA Binding Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Binding, Bridging 5'-3' DNA Helicase Activity Metal Ion Binding Protein N-terminus Binding 4 Iron, 4 Sulfur Cluster Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Mitotic Recombination Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleotide-excision Repair, DNA Duplex Unwinding Response To Hypoxia In Utero Embryonic Development Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Apoptotic Process Response To Oxidative Stress Chromosome Segregation Aging Cell Proliferation Response To UV UV Protection Post-embryonic Development Viral Process Spinal Cord Development Extracellular Matrix Organization Bone Mineralization Central Nervous System Myelin Formation Nucleotide-excision Repair, DNA Incision Multicellular Organism Growth Hair Cell Differentiation Embryonic Cleavage Erythrocyte Maturation Positive Regulation Of DNA Binding Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Recombination Embryonic Organ Development Hair Follicle Maturation Hematopoietic Stem Cell Differentiation Global Genome Nucleotide-excision Repair Regulation Of Mitotic Cell Cycle Phase Transition	Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript Cytosolic iron-sulfur cluster assembly NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Lung Cancer (DNA repair capacity) ( 23108145)
Interacting Genes		16 interacting genes: AR CDK1 CDK7 ERCC3 ERCC5 GTF2H1 GTF2H2 GTF2H2C_2 GTF2H3 HERC5 MNAT1 MTDH RAD51 RAD52 TP53 TRIM25	3 interacting genes: DZIP3 ERCC2 SUV39H1
Entrez ID		2068	730394
HPRD ID		00530	19238
Ensembl ID		ENSG00000104884
Uniprot IDs		P18074	Q6P1K8
PDB IDs		5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4
Enriched GO Terms of Interacting Partners?
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