ERCC1 and MKRN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ERCC1	MKRN3
Description		ERCC excision repair 1, endonuclease non-catalytic subunit	makorin ring finger protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex	Ribonucleoprotein Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Protein Binding Transferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Meiotic Mismatch Repair Pyrimidine Dimer Repair By Nucleotide-excision Repair Replicative Cell Aging DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organism Aging Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Post-embryonic Hemopoiesis Multicellular Organism Growth Response To Immobilization Stress Interstrand Cross-link Repair Isotype Switching Response To Cadmium Ion Oogenesis Embryonic Organ Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair UV-damage Excision Repair T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Protein Ubiquitination
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)	Height ( 31562340) Menarche (age at onset) ( 25231870) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		16 interacting genes: APP ERCC4 KIF11 MKRN3 RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	61 interacting genes: ANKRD11 BEX2 CRACR2A ENKD1 ERCC1 FAM110A FAM124B FARS2 GRAP2 KIF1A LRSAM1 MDM2 MDM4 MEOX2 MNAT1 MRPS6 NABP1 NDE1 NKAPD1 PEX10 PEX5 POLR1C PRPF31 PSMA1 RBM41 RBPMS RNF166 RNF32 RNF7 SCNM1 SF1 SFN TCEA2 TCHP TFAP2A TLE5 TRIM23 TRIM31 TRIM34 TRIM5 TRIM65 TRIM8 TSG101 TTC25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L3 UBE2N UBE2U UBE2V1 UBE2V2 UBE2W ZNF688
Entrez ID		2067	7681
HPRD ID		00533	04836
Ensembl ID		ENSG00000012061	ENSG00000179455
Uniprot IDs		A0A024R0Q6 P07992	Q13064
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT
Enriched GO Terms of Interacting Partners?
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