ERBB3 and PTGES3

Number of citations of the paper that reports this interaction (PubMedID 10095121)
4

Data Source:
HPRD (in vitro, two hybrid)

		ERBB3	PTGES3
Description		erb-b2 receptor tyrosine kinase 3	prostaglandin E synthase 3
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Chaperone Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding
	Biological Process	MAPK Cascade Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Peripheral Nervous System Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cranial Nerve Development Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Wound Healing Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Motility	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Xenobiotic Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Cyclooxygenase Pathway Positive Regulation Of Phosphorylation Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity Regulation Of Cellular Response To Heat Telomerase Holoenzyme Complex Assembly
Pathways			Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression
Drugs			Grn163l Copper
Diseases		Lethal congenital contractural syndrome (LCCS) Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Smoking initiation ( 30617275) Type 1 diabetes ( 21829393 19430480 18198356 17554260 17554300 18978792) Vitiligo ( 22951725)	Asthma ( 31619474) High light scatter reticulocyte percentage of red cells ( 27863252) Mean platelet volume ( 22139419) Platelet count ( 22139419)
Interacting Genes		100 interacting genes: ABL1 ABL2 AGTR2 BCAR3 CD82 CDC25C CDK5 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUPD1 DUSP14 DUSP18 DUSP19 DUSP21 EGF EGFR EGR1 ERBB2 ERBB4 EYA4 FER FGFR1 FLNA FLYWCH1 GRB2 GRB7 HCK HDAC6 IL6ST ILKAP ITK JAK2 JAK3 MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 NCK1 NCK2 NEDD4 NRG1 NRG2 ODF2L PA2G4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PPM1A PPM1B PPM1F PPM1K PPM1M PRKACA PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 SH2B3 SH2D1A SHC1 SHC3 SOS1 SRC SRPK2 STYX SYK TNS2 TNS3 TNS4 TPTE TXK VAV1 VAV2 VAV3 ZAP70 ZNF207	29 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPB1 NR3C1 NR3C2 STIP1 SURF1 TERT THRA
Entrez ID		2065	10728
HPRD ID		01820	06138
Ensembl ID		ENSG00000065361	ENSG00000110958
Uniprot IDs		P21860	A0A024RB32 A0A087WYT3 B3KUY2 Q15185
PDB IDs		1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6OP9	1EJF 1LG0
Enriched GO Terms of Interacting Partners?
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