EPAS1 and ARNTL

Number of citations of the paper that reports this interaction (PubMedID 9576906)
208

Data Source:
HPRD (two hybrid, in vivo)

		EPAS1	ARNTL
Description		endothelial PAS domain protein 1	aryl hydrocarbon receptor nuclear translocator like
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol Nuclear Speck	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex PML Body Chromatoid Body Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Aryl Hydrocarbon Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding Repressing Transcription Factor Binding E-box Binding
	Biological Process	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mitochondrion Organization Signal Transduction Visual Perception Protein Ubiquitination Erythrocyte Differentiation Lung Development Norepinephrine Metabolic Process Surfactant Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Myoblast Fate Commitment Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Transcription, DNA-templated Protein Import Into Nucleus Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Maternal Process Involved In Parturition Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Acetylation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells PTK6 Expression Neddylation Pexophagy	BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression Circadian Clock
Drugs
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Birth weight ( 31043758 27680694) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) Facial morphology ( 29921221) Hemoglobin levels ( 30188897) High altitude adaptation ( 28373541) Offspring birth weight ( 31043758) Oxygenated hemoglobin levels ( 30188897) P wave duration ( 28794112) Peak velocity of the mitral A-wave ( 28394258) Renal cell carcinoma ( 25826619 31231134 21131975)	Body mass index ( 25673413) C-reactive protein levels ( 30388399) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 27618448 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Face memory ( 31596458) Feeling guilty ( 29500382) Feeling miserable ( 29500382) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Iron status biomarkers (transferrin levels) ( 25352340) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Neurociticism ( 29500382) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Psoriasis ( 30921485) Schizophrenia ( 23358160) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		39 interacting genes: APC ARNT ARNT2 ARNTL ARNTL2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 ESR1 ETV4 EWSR1 F12 HSP90AA1 JUN KLHL20 KPNA1 KPNA3 KPNA5 KPNA6 KPNB1 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP VHL	21 interacting genes: AHR BHLHE40 CLOCK CRY1 CSNK1E DELEC1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 UBE2I
Entrez ID		2034	406
HPRD ID		06787	03973
Ensembl ID		ENSG00000116016	ENSG00000133794
Uniprot IDs		B3KW07 Q99814	A0A140VKD3 B2RCL8 O00327
PDB IDs		1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9 4PKY 4XT2 5KIZ 5TBM 5UFP 6BVB 6CZW 6D09 6D0B 6D0C 6I7R	4H10
Enriched GO Terms of Interacting Partners?
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