A2M and LCAT

Number of citations of the paper that reports this interaction (PubMedID 11435418)
9

Data Source:
HPRD (in vitro, in vivo)

		A2M	LCAT
Description		alpha-2-macroglobulin	lecithin-cholesterol acyltransferase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Phosphatidylcholine-sterol O-acyltransferase Activity Protein Binding Apolipoprotein A-I Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Esterification Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	HDL remodeling
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin
Diseases			Lecithin:cholesterol acyltransferase deficiency; Norum disease; Fish-eye disease
GWAS			HDL cholesterol ( 24097068 24507774 18193043 20864672 19060906 19060910 21347282 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 31217584) Schizophrenia ( 25056061 29483656) Total cholesterol levels ( 30275531) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		94 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS	4 interacting genes: A2M APOA1 APOE EXOSC10
Entrez ID		2	3931
HPRD ID		00072	06098
Ensembl ID		ENSG00000175899	ENSG00000213398
Uniprot IDs		P01023	A0A140VK24 P04180
PDB IDs		1BV8 2P9R 4ACQ	4X96 4XWG 4XX1 5BV7 5TXF 6MVD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?