ELANE and SERPIND1

Number of citations of the paper that reports this interaction (PubMedID 2318847)
10

Data Source:
HPRD (in vitro, in vivo)

		ELANE	SERPIND1
Description		elastase, neutrophil expressed	serpin family D member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Antimicrobial Humoral Response Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Gram-negative Bacterium Neutrophil Mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Chemotaxis Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin	Ardeparin Zinc Sulodexide Copper
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Inherited thrombophilia
GWAS		Blood protein levels ( 30072576)
Interacting Genes		30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	4 interacting genes: APP CTSG ELANE F2
Entrez ID		1991	3053
HPRD ID		00554	00795
Ensembl ID		ENSG00000197561	ENSG00000099937
Uniprot IDs		P08246	P05546 Q8IVC0
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M	1JMJ 1JMO 2NAT 2NCU 2NCV 2NCW 6J12 6KBO 6KBV
Enriched GO Terms of Interacting Partners?
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