AHSG and FBXO2

Number of citations of the paper that reports this interaction (PubMedID 12140560)
82

Data Source:
HPRD (in vivo)

		AHSG	FBXO2
Description		alpha 2-HS glycoprotein	F-box protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Cytoplasm Endoplasmic Reticulum Cytosol SCF Ubiquitin Ligase Complex Organelle Membrane Dendritic Spine
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Kinase Inhibitor Activity	Amyloid-beta Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development Platelet Degranulation Pinocytosis Acute-phase Response Negative Regulation Of Endopeptidase Activity Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Kinase Activity Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis	Protein Polyubiquitination Cellular Protein Modification Process Proteolysis Glycoprotein Catabolic Process Negative Regulation Of Cell Proliferation Protein Ubiquitination Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Post-translational Protein Modification
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Zinc Copper
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		8 interacting genes: CDC42 DCN FBXO2 FBXW7 GRB2 INSR RRAS2 VKORC1	13 interacting genes: AHSG BACE1 BRAP ECPAS IGH ITGB1 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3
Entrez ID		197	26232
HPRD ID		00727	06171
Ensembl ID		ENSG00000145192	ENSG00000116661
Uniprot IDs		P02765	Q9UK22
PDB IDs
Enriched GO Terms of Interacting Partners?
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