EIF2S1 and EIF2S2

Number of citations of the paper that reports this interaction (PubMedID 16288713)
3

Data Source:
HPRD (in vitro)

		EIF2S1	EIF2S2
Description		eukaryotic translation initiation factor 2 subunit alpha	eukaryotic translation initiation factor 2 subunit beta
Image
GO Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Translational Initiation Male Gonad Development Transmembrane Transport
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS			Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		24 interacting genes: CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12	24 interacting genes: AAR2 APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16
Entrez ID		1965	8894
HPRD ID		04881	04882
Ensembl ID		ENSG00000134001	ENSG00000125977
Uniprot IDs		P05198 Q53XC0	P20042 Q6IBR8
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z	6K71 6K72
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?