AGO4 and G3BP2

		AGO4	G3BP2
Description		argonaute RISC component 4	G3BP stress granule assembly factor 2
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane RISC Complex RISC-loading Complex	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MiRNA Binding	RNA Binding MRNA Binding Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	MRNA Catabolic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Wnt Signaling Pathway, Calcium Modulating Pathway Male Gonad Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cell Morphogenesis Pre-miRNA Processing Posttranscriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Apoptotic Process Regulation Of Megakaryocyte Differentiation MRNA Cleavage Involved In Gene Silencing By SiRNA	Cytoplasmic Sequestering Of NF-kappaB Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Viral Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS			Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)
Interacting Genes		5 interacting genes: APP G3BP2 TNRC6A TNRC6B TNRC6C	9 interacting genes: AGO4 CDKL2 MDM2 NFKB1 NFKBIA PHACTR2 PIN1 SDAD1 USO1
Entrez ID		192670	9908
HPRD ID		09559	06570
Ensembl ID		ENSG00000134698	ENSG00000138757
Uniprot IDs		Q9HCK5	A0A024RDB2 A0A024RDE5 Q9UN86
PDB IDs		6OON	5DRV
Enriched GO Terms of Interacting Partners?
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