AGO3 and BDNF

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		AGO3	BDNF
Description		argonaute RISC catalytic component 3	brain derived neurotrophic factor
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome P-body Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Synaptic Vesicle Nuclear Speck Secretory Granule Axon Dendrite Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Endoribonuclease Activity Protein Binding MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving MiRNA-paired MRNA	Protein Binding Growth Factor Activity
	Biological Process	MRNA Catabolic Process Wnt Signaling Pathway, Calcium Modulating Pathway RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Pre-miRNA Processing Posttranscriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Regulation Of Megakaryocyte Differentiation Regulation Of Stem Cell Proliferation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In Gene Silencing By SiRNA Positive Regulation Of NIK/NF-kappaB Signaling	Ureteric Bud Development Behavioral Fear Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Gamma-aminobutyric Acid Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Axon Guidance Axon Target Recognition Synapse Assembly Peripheral Nervous System Development Memory Circadian Rhythm Feeding Behavior Neuron Recognition Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Glutamate Secretion Dendrite Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Regulation Of Retinal Cell Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Collateral Sprouting Positive Regulation Of Collateral Sprouting Axon Extension Neuron Projection Morphogenesis Inner Ear Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Inhibitory Postsynaptic Potential Taste Bud Development Dendrite Extension Retrograde Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission Positive Regulation Of Receptor Binding Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs			CX717 Copper Chondroitin sulfate
Diseases			Congenital central hypoventilation syndrome (CCHS)
GWAS			Alcohol consumption ( 31358974) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 23563607 19079260 26961502 24861553 31453325 28892062 25673413 20935630 29273807 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Childhood body mass index ( 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 21708048 23563607) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260)
Interacting Genes		4 interacting genes: ATP4B ATP6V0D2 BDNF SLC22A2	16 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R INPP5K JUNB MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1
Entrez ID		192669	627
HPRD ID		09558	00214
Ensembl ID		ENSG00000126070	ENSG00000176697
Uniprot IDs		B4E1P5 Q9H9G7	A0A0E3SU01 P23560
PDB IDs		5VM9	1B8M 1BND
Enriched GO Terms of Interacting Partners?
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