EDN1 and CMA1

Number of citations of the paper that reports this interaction (PubMedID 9257865)
19

Data Source:
HPRD (in vitro)

		EDN1	CMA1
Description		endothelin 1	chymase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytoplasm Transport Vesicle Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cell Cytoplasm Secretory Granule Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Histamine Secretion Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of PH Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Heart Development Respiratory Gaseous Exchange Body Fluid Secretion Positive Regulation Of Cell Proliferation Dorsal/ventral Pattern Formation Response To Ozone Multicellular Organism Aging Positive Regulation Of Heart Rate Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Glucose Transmembrane Transport Positive Regulation Of Receptor Biosynthetic Process Neural Crest Cell Development Phosphatidylinositol 3-kinase Signaling Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Sensory Perception Of Pain Calcium-mediated Signaling Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Response To Nicotine Cellular Response To Drug Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Protein Kinase C Deactivation Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAP Kinase Activity Positive Regulation Of JUN Kinase Activity Response To Leptin Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Cartilage Development Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Membrane Depolarization Regulation Of Sensory Perception Of Pain Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Calcium Ion Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Endothelin Receptor Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of NIK/NF-kappaB Signaling Response To Salt Positive Regulation Of Vascular Smooth Muscle Cell Proliferation	Angiotensin Maturation Extracellular Matrix Disassembly Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Interleukin-1 Beta Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins
Drugs		TBC-3711	Benzylsulfinic Acid 2-(N-Morpholino)-Ethanesulfonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS		Body mass index ( 26426971) Circulating vasoactive peptide levels ( 23381795) Coronary artery disease ( 29212778) Multiple system atrophy ( 27629089) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Pulse pressure ( 30224653 30578418)
Interacting Genes		10 interacting genes: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4	10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Entrez ID		1906	1215
HPRD ID		07030	00346
Ensembl ID		ENSG00000078401	ENSG00000092009
Uniprot IDs		P05305 Q6FH53	P23946 Q4FEB3
PDB IDs		1EDN 1EDP 1T7H 1V6R 5GLH 6DK5	1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP
Enriched GO Terms of Interacting Partners?
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