DNMT1 and DCAF5

Number of citations of the paper that reports this interaction (PubMedID 29691401)
4

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		DNMT1	DCAF5
Description		DNA methyltransferase 1	DDB1 and CUL4 associated factor 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Nucleoplasm Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation DNA Methylation On Cytosine Within A CG Sequence Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing DNA Methylation Involved In Embryo Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine Positive Regulation Of Methylation-dependent Chromatin Silencing Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Protein Ubiquitination Post-translational Protein Modification
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation	Neddylation
Drugs		Azacitidine Procainamide Flucytosine Decitabine Epigallocatechin Gallate
Diseases
GWAS		Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Intelligence (MTAG) ( 29326435) Mean platelet volume ( 27863252) Neuroticism ( 29255261)
Interacting Genes		40 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNASE2 DNM2 DNMT3A DNMT3B DYNLL1 E2F6 EED ELAVL3 EZH2 GSK3B H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MECP2 NRIP1 PCNA PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UBB YWHAQ	1 interacting genes: DNMT1
Entrez ID		1786	8816
HPRD ID		00532	16032
Ensembl ID		ENSG00000130816	ENSG00000139990
Uniprot IDs		I6L9H2 P26358 Q59FP7	Q8TBB7 Q96JK2
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR	3I89
Enriched GO Terms of Interacting Partners?
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