DLST and DLG5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLST	DLG5
Description		dihydrolipoamide S-succinyltransferase	discs large MAGUK scaffold protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex	Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Cell Junction Ciliary Basal Body
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation	Epithelial To Mesenchymal Transition Signal Transduction Negative Regulation Of Cell Proliferation Maintenance Of Cell Polarity Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion
Pathways		Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)	Alanine transaminase levels ( 29403010) Gamma glutamyl transferase levels ( 29403010) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macular thickness ( 30535121) Obesity-related traits ( 23251661)
Interacting Genes		15 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1	8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		1743	9231
HPRD ID		00520	04972
Ensembl ID		ENSG00000119689	ENSG00000151208
Uniprot IDs		A0A024R6C9 B7Z6J1 P36957	Q8TDM6
PDB IDs			1UIT
Enriched GO Terms of Interacting Partners?
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