DHX9 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 11149922)
63

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		DHX9	GEMIN4
Description		DExH-box helicase 9	gem nuclear organelle associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Polysome Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex	Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Coiled Bodies
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding RNA Polymerase II Transcription Factor Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding ATP Binding ATPase Activity Nucleoside-triphosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity Importin-alpha Family Protein Binding RNA Polymerase Binding RISC Complex Binding Polysome Binding Single-stranded DNA-dependent ATP-dependent 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation DNA Replication DNA-templated Transcription, Termination Regulation Of Transcription By RNA Polymerase II Inflammatory Response RNA Secondary Structure Unwinding Targeting Of MRNA For Destruction Involved In RNA Interference Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Interleukin-18 Production Cellular Protein-containing Complex Assembly Positive Regulation Of Interferon-beta Secretion DNA-templated Viral Transcription G-quadruplex DNA Unwinding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Pyroptosis Small RNA Loading Onto RISC CRD-mediated MRNA Stabilization Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Positive Regulation Of Interferon-alpha Secretion Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Viral Translation Positive Regulation Of Polysome Binding Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Gene Silencing By MiRNA Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Interleukin-6 Secretion	Spliceosomal SnRNP Assembly RRNA Processing Import Into Nucleus
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway	snRNP Assembly
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Interacting Genes		40 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 EIF2AK2 ESR1 GEMIN2 GEMIN4 GTF2B H2AX HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 MBD2 NXF1 OGA PCNA POLR2A PRMT1 PRPF40A PRPF8 RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I YWHAQ	26 interacting genes: AGO2 CALCOCO2 DDX20 DHX9 DMPK FLAD1 GEMIN5 GLYR1 KARS1 LGALS1 LGALS3 MORC4 NUFIP1 PIAS3 RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD1 SNRPD2 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TOP1
Entrez ID		1660	50628
HPRD ID		04386	07370
Ensembl ID		ENSG00000135829	ENSG00000179409
Uniprot IDs		B3KU66 Q08211	I3L2C7 P57678 Q8WUM5
PDB IDs		3LLM 3VYX 3VYY
Enriched GO Terms of Interacting Partners?
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