GADD45A and PFKFB4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		GADD45A	PFKFB4
Description		growth arrest and DNA damage inducible alpha	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Cytosol
	Molecular Function	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding Promoter-specific Chromatin Binding	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity ATP Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPKKK Activity DNA Repair Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Mitotic Cell Cycle Arrest Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Dephosphorylation Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation
Pathways		TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Fructose-6-Phosphate
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533)	Bitter beverage consumption ( 31046077) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Mental health study participation (completed survey) ( 31263887) Morning person ( 30696823) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		67 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4-16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	4 interacting genes: CSNK2B GADD45A GSK3B PJA1
Entrez ID		1647	5210
HPRD ID		00528	05613
Ensembl ID		ENSG00000116717	ENSG00000114268
Uniprot IDs		A5JUZ3 P24522	B7Z5C3 Q16877 Q5XLC3 Q66S35
PDB IDs		2KG4
Enriched GO Terms of Interacting Partners?
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