DARS1 and EEF1A1

Number of citations of the paper that reports this interaction (PubMedID 7806521)
16

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		DARS1	EEF1A1
Description		aspartyl-tRNA synthetase 1	eukaryotic translation elongation factor 1 alpha 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Synapse Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Cortical Actin Cytoskeleton Ruffle Membrane Secretory Granule Lumen Extracellular Exosome Cytoplasmic Side Of Lysosomal Membrane Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Aminoacylase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding	TRNA Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Kinase Binding Protein Kinase Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation Protein-containing Complex Assembly	Translation Translational Elongation Neutrophil Degranulation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of D-erythro-sphingosine Kinase Activity Regulation Of Chaperone-mediated Autophagy
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation	Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy
Drugs		L-Aspartic Acid	Zinc Guanosine-5'-Diphosphate Copper Artenimol
Diseases
GWAS
Interacting Genes		4 interacting genes: AIMP2 EEF1A1 ESR1 PIK3R3	127 interacting genes: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 AQP2 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCDC130 CCL18 CDC25A CDKN1A CKS2 COX17 CRADD CRCT1 CSRP2 DARS1 DIABLO DLEU1 DUSP7 DYNLL1 EIF3F EP300 EXOSC4 FAS GADD45A GADD45G HSPB2 HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP PTPRF RAB27A RAP2A RBBP8 RFC5 RGS12 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB5 SERPINB9 SFN SHBG SMAD2 SMAD4 SMN1 SNCA SPP1 SSR1 STAT6 STMN2 SULT1E1 SUMO2 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSPY1 TSPYL2 TTR UBQLN4 WARS1 XPO5 XRN2 YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1
Entrez ID		1615	1915
HPRD ID		04361	00559
Ensembl ID		ENSG00000115866	ENSG00000156508
Uniprot IDs		A0A140VJW5 P14868	P68104 Q6IPS9
PDB IDs		4J15 5Y6L 6IY6	1SYW 3C5J
Enriched GO Terms of Interacting Partners?
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