DAPK1 and PRKAG2

Number of citations of the paper that reports this interaction (PubMedID 29513927)
4

Data Source:
BioGRID (pull down)

		DAPK1	PRKAG2
Description		death associated protein kinase 1	protein kinase AMP-activated non-catalytic subunit gamma 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Actin Cytoskeleton	Extracellular Space Nucleoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding GTP Binding Syntaxin-1 Binding Identical Protein Binding	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Translation Intracellular Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Autophosphorylation Cellular Response To Interferon-gamma Cellular Response To Hydroperoxide Apoptotic Signaling Pathway Regulation Of NMDA Receptor Activity	Glycogen Metabolic Process Regulation Of Glycolytic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE	Acetylsalicylic acid
Diseases		Bladder cancer	Hypertrophic cardiomyopathy (HCM)
GWAS		Blood pressure ( 24954895) Cognitive function ( 24684796) Height ( 31562340) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Night sleep phenotypes ( 27126917) Ovarian cancer ( 30557369) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to gemcitabine in pancreatic cancer ( 22293537)	Bipolar disorder (age of onset and psychotic symptoms) ( 21305692) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Gut microbiota (beta diversity) ( 27723756) Hematocrit ( 27863252 28017375 19862010) Hemoglobin ( 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) Intraocular pressure ( 29785010 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Pulse pressure ( 27841878 30578418) Red blood cell count ( 28453575 27863252) Red blood cell traits ( 23222517) Systolic blood pressure ( 27841878 27618447 30578418) Urate levels ( 31578528 23263486) Urea levels ( 31015462 28270201)
Interacting Genes		108 interacting genes: ABL1 ABLIM1 AHDC1 APEX2 ARRDC1 ARRDC1-AS1 ATF6 BAG2 BAIAP2 C11orf65 CALM1 CAPRIN1 CBLB CCDC149 CDC42EP3 CDC42SE1 CMTM4 CNTROB DENND1C DTWD1 DUS1L DUX3 EPHA1 FADD FAM107A FAM126B FBXL14 FBXW11 FIBP GASK1B GTF2F1 IKBKG JHY KLHL20 LIMA1 LIMS1 LINC02875 LMF2 LNX1 LOXL2 MAPK1 MAPK3 MCM10 MDM2 MIB1 MRGBP MTHFD2 MYL12B NCBP3 NECAB1 NECAP1 NR3C1 ORMDL2 PAK6 PAPSS2 PCP4 PHKG2 PIM1 PIM2 POLR2M PPP1R14A PPP2R1A PPP2R2D PPP2R5A PRKAG2 PRR16 PWP1 RAPGEF3 RASGRP2 RCHY1 RFC5 RHBDD1 RPAP3 RPL41 SARNP SCEL SCRN3 SCYL1 SGK2 SH2D2A SLAIN2 SNRPA SNURF SNX9 SPATS2 SPRR2G SRSF10 STARD3 STUB1 STX1A TAS2R60 TBC1D22B TNFRSF1A TPD52L1 TRADD TRAPPC2 TTC27 TUBB4B UNC5A UNC5B UNC5C VGLL4 VN1R1 WWTR1 YWHAB ZAP70 ZMAT4 ZMYM5	6 interacting genes: CHPF2 DAPK1 MFHAS1 PRKAB1 PRKAB2 PRKAG1
Entrez ID		1612	51422
HPRD ID		02902	04119
Ensembl ID		ENSG00000196730	ENSG00000106617
Uniprot IDs		B4DHI4 P53355 Q59H88	A0A090N8Q6 A0A384MDZ2 A0A494C068 A0A494C1K7 B7Z6X8 E9PGP6 Q9UGJ0
PDB IDs		1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L 4PF4 4TL0 4TXC 4UV0 4YO4 4YPD 5AUT 5AUU 5AUV 5AUW 5AUX 5AUY 5AUZ 5AV0 5AV1 5AV2 5AV3 5AV4 6AAR 6FHA 6FHB 6GY5 6IN4 6QMO 6QN4
Enriched GO Terms of Interacting Partners?
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