AP2A2 and SNAP91

Number of citations of the paper that reports this interaction (PubMedID 10430869)
50

Data Source:
HPRD (in vitro)

		AP2A2	SNAP91
Description		adaptor related protein complex 2 subunit alpha 2	synaptosome associated protein 91
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Ficolin-1-rich Granule Membrane	Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Clathrin-coated Vesicle Presynaptic Membrane Extrinsic Component Of Presynaptic Endocytic Zone Membrane
	Molecular Function	Molecular_function Protein Binding Lipid Binding Protein Kinase Binding Clathrin Adaptor Activity Disordered Domain Specific Binding	SNARE Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Kinase Binding Clathrin Heavy Chain Binding
	Biological Process	Intracellular Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Neutrophil Degranulation Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis	Endocytosis Vesicle Budding From Membrane Protein Transport Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Electrodermal activity ( 25387706) Macular thickness ( 30535121) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		22 interacting genes: AMPH AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EGFR EPN1 EPS15 HTT ILK KCNQ1DN LRPPRC NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC ZPR1	9 interacting genes: AP2A2 AP2B1 DNAJC5 EPS15 NECAP1 OGT PLCG1 TRAF3IP1 TUBA1B
Entrez ID		161	9892
HPRD ID		06256	06391
Ensembl ID		ENSG00000183020	ENSG00000065609
Uniprot IDs		O94973	B7Z2N2 E9PDG8 H0UI15 O60641
PDB IDs
Enriched GO Terms of Interacting Partners?
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