CYP51A1 and ZNF420

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CYP51A1	ZNF420
Description		cytochrome P450 family 51 subfamily A member 1	zinc finger protein 420
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane	Nucleoplasm
	Molecular Function	Iron Ion Binding Sterol 14-demethylase Activity Oxidoreductase Activity Heme Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Sterol Metabolic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Negative Regulation Of Protein Catabolic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Protein Secretion Oxidation-reduction Process Demethylation Negative Regulation Of Amyloid-beta Clearance	Regulation Of Transcription, DNA-templated Regulation Of Apoptotic Process
Pathways		Cholesterol biosynthesis Endogenous sterols Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination	Generic Transcription Pathway TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs		Metronidazole Tioconazole Rifampicin Itraconazole 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lifespan ( 25918517) Pulse pressure ( 30578418)	Prudent dietary pattern ( 28644415)
Interacting Genes		1 interacting genes: ZNF420	10 interacting genes: CDC42 CDK2AP1 CDKN2A CYP4V2 CYP51A1 HAX1 MDM2 SLC1A7 TNFRSF1B TRIM28
Entrez ID		1595	147923
HPRD ID		03381	08122
Ensembl ID		ENSG00000001630	ENSG00000197050
Uniprot IDs		A0A0C4DFL7 Q16850	Q8TAQ5
PDB IDs		3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T
Enriched GO Terms of Interacting Partners?
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