CYP19A1 and FANCG

Number of citations of the paper that reports this interaction (PubMedID 11756225)
40

Data Source:
HPRD (in vitro)

		CYP19A1	FANCG
Description		cytochrome P450 family 19 subfamily A member 1	FA complementation group G
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nucleoplasm Nucleolus Mitochondrion Cytosol Plasma Membrane Fanconi Anaemia Nuclear Complex
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity	Damaged DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Chronic Inflammatory Response Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process Female Gonad Development Negative Regulation Of Macrophage Chemotaxis Sterol Metabolic Process Electron Transport Chain Female Genitalia Development Mammary Gland Development Uterus Development Prostate Gland Growth Testosterone Biosynthetic Process Positive Regulation Of Estradiol Secretion	Ovarian Follicle Development DNA Repair Cellular Response To DNA Damage Stimulus Mitochondrion Organization Spermatid Development Response To Radiation Interstrand Cross-link Repair
Pathways		Estrogen biosynthesis Endogenous sterols Defective CYP19A1 causes Aromatase excess syndrome (AEXS)	Fanconi Anemia Pathway
Drugs		Nicotine Aminoglutethimide Estrone Testolactone Exemestane Letrozole Ketoconazole Anastrozole 2-Methoxyestradiol Naringenin Glyphosate MPI-674
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Aromatase excess syndrome	Fanconi anemia
GWAS		Airway wall thickness ( 25517131) Breast cancer ( 31757997) Cerebrospinal fluid AB1-42 levels ( 20932310) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Estradiol levels ( 22675492 29325096) Estrone levels ( 29325096) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Follicule stimulating hormone ( 24049095) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 25429064 31562340 23456168 20189936) Hormone measurements ( 24049095) Menarche (age at onset) ( 23599027) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 29403010) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378)
Interacting Genes		1 interacting genes: FANCG	42 interacting genes: BRCA2 BRCC3 CAPN1 CBY2 CDK1 COG6 CTBP1 CYP19A1 CYP2E1 DOK5 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 GATA1 GOLGA2 HES1 HGS IHO1 IKZF3 KRT13 KRT19 LNX2 MEOX2 NECAB2 NLGN3 PSMB1 RINT1 RTN2 SAMD3 SSX2IP TADA2A TFIP11 TLE5 UIMC1 USHBP1 XRCC3 ZBED1 ZBTB1
Entrez ID		1588	2189
HPRD ID		00488	04262
Ensembl ID		ENSG00000137869	ENSG00000221829
Uniprot IDs		A0A024R5S8 A8K6W3 P11511 Q05CU4 Q8IYG4 Q8TCA4	O15287 Q53XM5
PDB IDs		1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8 5JKV 5JKW 5JL6 5JL7 5JL9
Enriched GO Terms of Interacting Partners?
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