CYP11B2 and CYP11B1

Number of citations of the paper that reports this interaction (PubMedID 10411633)
2

Data Source:
HPRD (in vitro)

		CYP11B2	CYP11B1
Description		cytochrome P450 family 11 subfamily B member 2	cytochrome P450 family 11 subfamily B member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Corticosterone 18-monooxygenase Activity	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Heme Binding Corticosterone 18-monooxygenase Activity
	Biological Process	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Oxidation-reduction Process Cellular Response To Peptide Hormone Stimulus	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Immune Response Cholesterol Metabolic Process Regulation Of Blood Pressure Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Glucose Homeostasis Oxidation-reduction Process Cellular Response To Peptide Hormone Stimulus
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Drugs		Spironolactone	Mitotane Metyrapone
Diseases		Glucocorticoid-remediable aldosteronism (GRA) Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency	Glucocorticoid-remediable aldosteronism (GRA) Congenital adrenal hyperplasia (CAH) 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)	Hypertension ( 30487518) Mean arterial pressure ( 30487518) Pulse pressure ( 30487518) Systolic blood pressure ( 29403010)
Interacting Genes		3 interacting genes: CYP11A1 CYP11B1 FDX1	1 interacting genes: CYP11B2
Entrez ID		1585	1584
HPRD ID		00492	01943
Ensembl ID		ENSG00000179142	ENSG00000160882
Uniprot IDs		P19099	P15538 Q8TDD0
PDB IDs		4DVQ 4FDH 4ZGX	6M7X
Enriched GO Terms of Interacting Partners?
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