CYP2C9 and RAB3D

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid)

		CYP2C9	RAB3D
Description		cytochrome P450 family 2 subfamily C member 9	RAB3D, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Endosome Cytoplasmic Microtubule Plasma Membrane Synaptic Vesicle Endomembrane System Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Zymogen Granule Extracellular Exosome Secretory Vesicle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity Aromatase Activity	GTPase Activity GTP Binding GTP-dependent Protein Binding Myosin V Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Amide Metabolic Process Icosanoid Biosynthetic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Peptidyl-cysteine Methylation Rab Protein Signal Transduction Neutrophil Degranulation Bone Resorption Protein Localization To Plasma Membrane Positive Regulation Of Regulated Secretory Pathway
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs	Neutrophil degranulation RAB geranylgeranylation
Drugs		4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One Heme C Diacerein Benzbromarone
Diseases
GWAS		Blood metabolite levels ( 24816252) Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 28207573 19706858) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499 26265036)	Early cardiac repolarization ( 31600170) HDL cholesterol ( 23505323)
Interacting Genes		10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	12 interacting genes: AKT1 AKT2 AP1M2 APP CEP55 CHM CYP2C9 MAST1 RAB3IP RIMS2 RNF32 RPH3AL
Entrez ID		1559	9545
HPRD ID		03084	05070
Ensembl ID		ENSG00000138109	ENSG00000105514
Uniprot IDs		P11712 S5RV20	A0A024R7G2 O95716
PDB IDs		1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI	2GF9
Enriched GO Terms of Interacting Partners?
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