AGR3 and DAG1

Number of citations of the paper that reports this interaction (PubMedID 12592373)
48

Data Source:
HPRD (two hybrid)

		AGR3	DAG1
Description		anterior gradient 3, protein disulphide isomerase family member	dystroglycan 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Intracellular Membrane-bounded Organelle	Extracellular Region Basement Membrane Extracellular Space Cell Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Node Of Ranvier Nuclear Periphery Sarcolemma Costamere Plasma Membrane Raft Postsynaptic Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Contractile Ring Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol
	Molecular Function	Dystroglycan Binding Protein Binding	Virus Receptor Activity Dystroglycan Binding Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding SH2 Domain Binding Laminin-1 Binding Alpha-actinin Binding
	Biological Process	Biological_process Negative Regulation Of Cell Death	Positive Regulation Of Cell-matrix Adhesion Morphogenesis Of An Epithelial Sheet Membrane Protein Ectodomain Proteolysis Cytoskeletal Anchoring At Plasma Membrane Aging Regulation Of Gastrulation Regulation Of Epithelial To Mesenchymal Transition Response To Denervation Involved In Regulation Of Muscle Adaptation Calcium-dependent Cell-matrix Adhesion Regulation Of Embryonic Cell Shape Modulation By Virus Of Host Morphology Or Physiology Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Axon Regeneration Positive Regulation Of Myelination Microtubule Anchoring Skeletal Muscle Tissue Regeneration Negative Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Viral Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Synapse Organization Negative Regulation Of Protein Kinase B Signaling Angiogenesis Involved In Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Cholesterol Commissural Neuron Axon Guidance Basement Membrane Organization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways			Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS		Coffee consumption ( 29367735) Cutaneous malignant melanoma ( 26237428) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Pediatric autoimmune diseases ( 26301688) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: AKT1 APC ASB10 BCAR3 BZW2 CASP8 DAG1 ERLIN1 ESR2 LYPD3 NUP62 PTPN1 SGTA TGFB1 UBQLN1	25 interacting genes: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2
Entrez ID		155465	1605
HPRD ID		16545	00546
Ensembl ID		ENSG00000173467	ENSG00000173402
Uniprot IDs		Q8TD06	A0A024R2W4 Q14118
PDB IDs		3PH9	1EG4 2MK7 5GGP 5LLK 6JJY
Enriched GO Terms of Interacting Partners?
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