CYP1A2 and CYB5A

Number of citations of the paper that reports this interaction (PubMedID 15680923)
23

Data Source:
BioGRID (pull down)

		CYP1A2	CYB5A
Description		cytochrome P450 family 1 subfamily A member 2	cytochrome b5 type A
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity	Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Toxin Biosynthetic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Drug Metabolic Process Dibenzo-p-dioxin Metabolic Process Epoxygenase P450 Pathway Electron Transport Chain Lung Development Methylation Response To Estradiol Response To Lipopolysaccharide Monocarboxylic Acid Metabolic Process Response To Immobilization Stress Retinol Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Respiration Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidation-reduction Process Oxidative Demethylation Cellular Response To Cadmium Ion Cellular Response To Copper Ion Oxidative Deethylation Omega-hydroxylase P450 Pathway	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport
Pathways		Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs	Vitamin C (ascorbate) metabolism
Drugs		Isoniazid 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE Diacerein	Dimethyl Propionate Ester Heme
Diseases			Methemoglobinemia
GWAS		Bladder cancer ( 25281661) Caffeine consumption ( 21490707) Coffee consumption ( 21876539 21357676 25288136) Coffee consumption (cups per day) ( 25288136) Diastolic blood pressure ( 19430483) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Red blood cell count ( 27863252) Serum albumin level ( 29403010) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Blood protein levels ( 30072576)
Interacting Genes		2 interacting genes: CYB5A POR	14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4
Entrez ID		1544	1528
HPRD ID		00489	08941
Ensembl ID		ENSG00000140505	ENSG00000166347
Uniprot IDs		P05177	A0A384ME44 P00167
PDB IDs		2HI4	2I96
Enriched GO Terms of Interacting Partners?
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