CTNNA2 and CTNNBIP1

Number of citations of the paper that reports this interaction (PubMedID 16325583)
375

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		CTNNA2	CTNNBIP1
Description		catenin alpha 2	catenin beta interacting protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Adherens Junction Actin Cytoskeleton Basolateral Plasma Membrane Lamellipodium Axon Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Postsynaptic Density, Intracellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding Beta-catenin Binding Armadillo Repeat Domain Binding
	Biological Process	Cytoskeleton Organization Axonogenesis Regulation Of Neuron Projection Development Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendrite Morphogenesis Brain Morphogenesis Positive Regulation Of Muscle Cell Differentiation Regulation Of Synapse Structural Plasticity Prepulse Inhibition Cell-cell Adhesion Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Neuron Migration	Branching Involved In Ureteric Bud Morphogenesis Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Anterior/posterior Pattern Specification Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Mesenchymal Cell Proliferation
Pathways		Myogenesis Myogenesis	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Alcohol consumption ( 28937693) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 19416921) Body mass index ( 26426971 25673413) Bone mineral density (femoral neck) ( 26911590) Breast cancer ( 25824743) Cerebral microbleeds ( 31209788) Cerebrospinal fluid clusterin levels ( 26545630) Cleft palate ( 30452639) Cognitive function ( 25644384) Contrast sensitivity ( 24152035) Mild influenza (H1N1) infection ( 26379185) Multisite chronic pain ( 31194737) Orthostatic hypotension ( 24124408) Protein quantitative trait loci ( 18464913) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to lurasidone in schizophrenia ( 29730043) Survival in pancreatic cancer ( 28470677)	Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		3 interacting genes: CTNNBIP1 PTPN14 TOMM70	11 interacting genes: BEND5 CTNNA2 CTNNB1 EMD INCA1 JUP KRTAP10-3 KRTAP10-7 REL TCF7L2 USHBP1
Entrez ID		1496	56998
HPRD ID		00228	09677
Ensembl ID		ENSG00000066032	ENSG00000178585
Uniprot IDs		F6KRI5 P26232 Q49AD3	A0A024R4D7 Q9NSA3
PDB IDs		6DUW	1LUJ 1M1E 1T08
Enriched GO Terms of Interacting Partners?
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