CTNNA1 and CDH5

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CTNNA1	CDH5
Description		catenin alpha 1	cadherin 5
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Flotillin Complex Lamellipodium Cell Junction Intracellular Membrane-bounded Organelle	Cell Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Ion Channel Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding
	Biological Process	Ovarian Follicle Development Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Morphogenesis Regulation Of Protein Phosphorylation Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Vascular Permeability Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs	Adherens junctions interactions VEGFR2 mediated vascular permeability
Drugs			Lenalidomide FX06
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061)	Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034)
Interacting Genes		31 interacting genes: ACTN1 AFDN AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 DLG1 JUP LRATD2 MTNR1A MTNR1B OBI1 PKD1 PSEN1 SASH1 SPTAN1 SPTBN1 TJP1 TJP2 UBE2I VCL ZGPAT	21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		1495	1003
HPRD ID		00285	03075
Ensembl ID		ENSG00000044115	ENSG00000179776
Uniprot IDs		A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221	P33151 Q59EA3
PDB IDs		1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?
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