CSNK1A1 and CHRM3

Number of citations of the paper that reports this interaction (PubMedID 10777483)
23

Data Source:
HPRD (in vitro)

		CSNK1A1	CHRM3
Description		casein kinase 1 alpha 1	cholinergic receptor muscarinic 3
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Keratin Filament Ribonucleoprotein Complex	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Cell Junction Dendrite Axon Terminus Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Signaling Receptor Activity Acetylcholine Binding
	Biological Process	Cell Morphogenesis Protein Phosphorylation Golgi Organization Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of GTP Binding Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly	Regulation Of Vascular Smooth Muscle Contraction Cellular Protein Modification Process Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Saliva Secretion G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Vascular Smooth Muscle Contraction
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO	Muscarinic acetylcholine receptors Acetylcholine regulates insulin secretion G alpha (q) signalling events
Drugs			Cevimeline Tramadol Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Loxapine Carbachol Promazine Hyoscyamine Cyproheptadine Pethidine Imipramine Methylscopolamine bromide Chlorpromazine Darifenacin Tridihexethyl Anisotropine Methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Thiopental Nicardipine Paroxetine Homatropine Methylbromide Trimipramine Diphemanil Methylsulfate Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine Arecoline Mepenzolate Itopride ALKS 27 Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Dosulepin Etoperidone Imidafenacin Butylscopolamine Dexpanthenol
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)	Chronic obstructive pulmonary disease ( 30804561) Colorectal cancer ( 29228715) Depression in smokers ( 30219690) Electroencephalogram traits ( 25387704) Feeling worry ( 29500382) FEV1 ( 30804560) Generalized epilepsy ( 22949513) Hallucinations in long-term cannabis use ( 31740666) Hypertension ( 17554300) Interleukin-6 (red blood cell fatty acid level interaction) ( 28820441) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) Platelet count ( 21507922) Post bronchodilator FEV1 ( 26634245) Reflection (response to stress) ( 30886212) Sulfasalazine-induced agranulocytosis ( 28762467) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		48 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CRBN CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 UVRAG YWHAQ YWHAZ ZRANB1	10 interacting genes: ARF1 ARF6 CSNK1A1 GNAQ GPRASP1 GRK6 GZMB PPP1R9B RGS7 SET
Entrez ID		1452	1131
HPRD ID		02739	00329
Ensembl ID		ENSG00000113712	ENSG00000133019
Uniprot IDs		B4DER9 P48729 Q6PJ06	A0A024R3W1 P20309
PDB IDs		5FQD 6GZD	2CSA
Enriched GO Terms of Interacting Partners?
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