CSF2RB and IL5RA

Number of citations of the paper that reports this interaction (PubMedID 9516124)
16

Data Source:
HPRD (in vivo)

		CSF2RB	IL5RA
Description		colony stimulating factor 2 receptor subunit beta	interleukin 5 receptor subunit alpha
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Signaling Receptor Activity	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	MAPK Cascade Signal Transduction Respiratory Gaseous Exchange Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Cellular Protein Metabolic Process	MAPK Cascade Inflammatory Response To Antigenic Stimulus Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Sargramostim NPI 32101 Resatorvid	Benralizumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)	Asthma (childhood onset) ( 22560479) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Oleic acid (18:1n-9) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ	7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		1439	3568
HPRD ID		00739	00998
Ensembl ID		ENSG00000100368	ENSG00000091181
Uniprot IDs		P32927 Q6NSJ8	A0A024R2E8 Q01344 Q8NHV7
PDB IDs		1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU	1OBX 1OBZ 3QT2 3VA2 6H41
Enriched GO Terms of Interacting Partners?
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