PARP1 and ZBTB16

Number of citations of the paper that reports this interaction (PubMedID 17340613)
10

Data Source:
BioGRID (enzymatic study)

		PARP1	ZBTB16
Description		poly(ADP-ribose) polymerase 1	zinc finger and BTB domain containing 16
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GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Transcription Factor Complex Nucleolus Mitochondrion Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Site Of DNA Damage	Nucleus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcriptional Repressor Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Estrogen Receptor Binding Identical Protein Binding Histone Deacetylase Binding Protein N-terminus Binding NAD Binding R-SMAD Binding Protein ADP-ribosylase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Transcription By RNA Polymerase II Protein ADP-ribosylation Apoptotic Process Cellular Response To DNA Damage Stimulus Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of SMAD Protein Complex Assembly Protein Autoprocessing Peptidyl-serine ADP-ribosylation Peptidyl-glutamic Acid Poly-ADP-ribosylation Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleotide-excision Repair, DNA Incision Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process DNA Damage Response, Detection Of DNA Damage Mitochondrial DNA Repair Regulation Of DNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Global Genome Nucleotide-excision Repair Cellular Response To Zinc Ion Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Neuron Death Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Single Strand Break Repair Regulation Of Cellular Protein Localization Response To Aldosterone Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Generation From Poly-ADP-D-ribose Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of ATP Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Mesonephros Development Regulation Of Transcription, DNA-templated Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Regulation Of Gene Expression Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways		POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Theophylline Zinc Carba-Nicotinamide-Adenine-Dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Niraparib Rucaparib
Diseases			Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)
GWAS		Coronary artery disease ( 29212778) Leukocyte telomere length ( 31171785) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 29403010) Telomere length ( 29151059)	Chronotype ( 30696823) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Corneal astigmatism ( 29422769) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Mean platelet volume ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Non-glioblastoma glioma ( 28346443 26424050) Paneth cell defects in Crohn's disease ( 28352666) Platelet count ( 27863252) Plateletcrit ( 27863252) Polycystic ovary syndrome ( 26284813 30566500) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		99 interacting genes: APTX ATM BCL2 BLID BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTCF CTSB CTSG E2F1 ERCC6 ERG ETS1 FOXO1 GTF2F1 GZMB GZMM H1-0 H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-3A H3-4 H4C3 HDAC1 HDAC3 HIPK2 HMGA1 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LZTR1 MACROH2A1 MED14 MED6 MTA3 MYBL2 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF144A RNF168 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 UBE2I UHRF1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423	115 interacting genes: ACP5 ADAMTS4 AGTR2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BMI1 CASP3 CCDC130 CCDC85B CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 DLST DNAAF5 DNM2 DPM1 EEF1A1 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FCHO1 FHL2 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX ICAM3 IL6 KIAA1549 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MX1 NCOR1 NCOR2 NR3C1 PAFAH1B3 PARP1 PGAM5 PLSCR1 PMAIP1 PML PNRC2 PSMD11 PSMD2 QTRT1 RAB27A RARA RB1 RFLNB RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TOLLIP TRAF1 TRAF2 TRIM27 TRIM54 TXNIP UBE2I VDR VTA1 WDR33 ZBTB32 ZNF24 ZNF281
Entrez ID		142	7704
HPRD ID		01435	11762
Ensembl ID		ENSG00000143799	ENSG00000109906
Uniprot IDs		A0A024R3T8 P09874	A0A024R3C6 Q05516
PDB IDs		1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6NRF 6NRG 6NRH 6NRI 6NRJ	1BUO 1CS3
Enriched GO Terms of Interacting Partners?
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