CRHR1 and MAGI3

Number of citations of the paper that reports this interaction (PubMedID 23576434)
13

Data Source:
BioGRID (pull down)

		CRHR1	MAGI3
Description		corticotropin releasing hormone receptor 1	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Neuron Projection	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction
	Molecular Function	Protein Binding Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Female Pregnancy Parturition Hormone-mediated Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G Protein-coupled Receptor Signaling Pathway Corticotropin Secretion Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Corticosterone Secretion	Apoptotic Process Signal Transduction Viral Process Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Corticorelin ovine triflutate
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Cerebral white matter volume ( 31530798) General factor of neuroticism ( 30867560) Granulocyte count ( 27863252) Head circumference (infant) ( 22504419) Headache ( 29397368) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Intake of total sugars ( 31005972) Intracranial volume ( 22504418) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Male-pattern baldness ( 28196072) Maximum habitual alcohol consumption ( 31151762) Medication use (antithrombotic agents) ( 31015401) Monobrow ( 27182965) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neuroticism ( 29255261) Neutrophil count ( 27863252) Parkinson's disease ( 31660654 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cirrhosis ( 22961000) Subcortical brain region volumes ( 25607358) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Alopecia areata ( 25608926) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Obesity-related traits ( 23251661) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		18 interacting genes: CALM1 CRH DLG1 DLG4 GNAI1 GNAO1 GNAQ GNAS GOPC MAGI1 MAGI2 MAGI3 MPDZ PDZK1 PTPN13 SRPK1 UCN UCN3	16 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2
Entrez ID		1394	260425
HPRD ID		08830	11290
Ensembl ID		ENSG00000120088	ENSG00000081026
Uniprot IDs		A0A024R9X9 B3SXS2 B3TIK8 G3CIS4 K9J956 P34998	Q5TCQ9
PDB IDs		2L27 3EHS 3EHT 3EHU 4K5Y 4Z9G	3SOE
Enriched GO Terms of Interacting Partners?
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