CPN1 and KNG1

Number of citations of the paper that reports this interaction (PubMedID 14687935)
42

Data Source:
HPRD (in vitro)

		CPN1	KNG1
Description		carboxypeptidase N subunit 1	kininogen 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Cell Endoplasmic Reticulum Lumen Plasma Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	Peptide Metabolic Process Bradykinin Catabolic Process Protein Processing Regulation Of Complement Activation Response To Glucocorticoid	Platelet Degranulation Inflammatory Response Negative Regulation Of Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Vasodilation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Proteolysis
Pathways		Regulation of Complement cascade	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation
Drugs		Zinc	Zinc Copper
Diseases
GWAS		Blood protein levels ( 29875488 28240269 23696881) Creatine kinase levels ( 29403010) Dermatomyositis ( 27153935) Femoral neck bone mineral density ( 22504420) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757)	Activated partial thromboplastin time ( 22703881 29403010 20303064) Adiponectin levels ( 20876611) Blood metabolite levels ( 24816252) Blood protein levels ( 30072576 29875488 28240269) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)
Interacting Genes		7 interacting genes: C3 C5 CDC42 CLEC4G CPN2 KNG1 STC2	28 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN
Entrez ID		1369	3827
HPRD ID		09120	01970
Ensembl ID		ENSG00000120054	ENSG00000113889
Uniprot IDs		P15169	P01042
PDB IDs		2NSM	1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y
Enriched GO Terms of Interacting Partners?
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