CLDN4 and TJP1

Number of citations of the paper that reports this interaction (PubMedID 10601346)
287

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CLDN4	TJP1
Description		claudin 4	tight junction protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding	Protein Binding Calmodulin Binding Cadherin Binding
	Biological Process	Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Establishment Of Skin Barrier Renal Absorption Positive Regulation Of Wound Healing Chloride Transmembrane Transport Positive Regulation Of Metallopeptidase Activity	Cell-cell Junction Assembly Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Hippo Signaling Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways		Tight junction interactions	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS			Central corneal thickness ( 31798171 29760442 30894546) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Interacting Genes		4 interacting genes: EPHA2 SHBG TJP1 WNK4	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 OCLN PEA15 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		1364	7082
HPRD ID		04218	03002
Ensembl ID		ENSG00000189143	ENSG00000104067
Uniprot IDs		O14493 Q75L80	A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157 Q6MZU1
PDB IDs		5B2G	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?
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