COMT and ACE

Number of citations of the paper that reports this interaction (PubMedID 12729939)
5

Data Source:
HPRD (in vivo)

		COMT	ACE
Description		catechol-O-methyltransferase	angiotensin I converting enzyme
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Dendritic Spine Intracellular Membrane-bounded Organelle Cell Body Postsynaptic Membrane Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity	Endopeptidase Activity Carboxypeptidase Activity Drug Binding Metallopeptidase Activity Exopeptidase Activity Dipeptidyl-peptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Mitogen-activated Protein Kinase Binding Metallodipeptidase Activity
	Biological Process	Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Response To Drug Response To Estrogen Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Regulation Of Renal Output By Angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Systemic Arterial Blood Pressure Proteolysis Spermatogenesis Regulation Of Blood Pressure Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Mononuclear Cell Proliferation Hormone Catabolic Process Peptide Catabolic Process Positive Regulation Of Blood Pressure Amyloid-beta Metabolic Process Arachidonic Acid Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Cell Proliferation In Bone Marrow Regulation Of Blood Vessel Diameter Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways		Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase	Metabolism of Angiotensinogen to Angiotensins
Drugs		Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one	Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril
Diseases			Renal tubular dysgenesis Allograft rejection
GWAS		Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 24162737 30820047) Angiotensin-converting enzyme activity ( 20066004) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 30072576) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 28135244 27841878 28739976) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 21886157) Metabolite levels ( 23281178) Serum metabolite levels ( 24625756 23093944) Systolic blood pressure ( 27841878 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 2 diabetes ( 30297969)
Interacting Genes		17 interacting genes: ACE BRS3 CDC27 GLP1R HCK HOPX KRT31 KRT40 KRTAP5-9 LITAF MRPS5 MTNR1A RGS2 TRIP13 VKORC1 XRN2 ZNF43	5 interacting genes: AGTR2 BDKRB2 COMT CSNK2A1 DCAF7
Entrez ID		1312	1636
HPRD ID		00284	00108
Ensembl ID		ENSG00000093010	ENSG00000159640
Uniprot IDs		A0A140VJG8 P21964	B4DKH4 P12821
PDB IDs		3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D	1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P 4C2Q 4C2R 4CA5 4CA6 4UFA 4UFB 5AM8 5AM9 5AMA 5AMB 5AMC 6EN5 6EN6 6F9R 6F9T 6F9U 6F9V 6H5W 6H5X 6QS1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?