EDARADD and EDAR

Number of citations of the paper that reports this interaction (PubMedID 11882293)
16

Data Source:
HPRD (in vitro)

		EDARADD	EDAR
Description		EDAR associated death domain	ectodysplasin A receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Multicellular Organism Development Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic	Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Urate levels (BMI interaction) ( 25811787)	Beard thickness ( 26926045) Blood protein levels ( 30072576 29875488 28240269) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819)
Interacting Genes		10 interacting genes: EDAR NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I	6 interacting genes: EDA EDARADD MAP3K14 TRAF1 TRAF2 TRAF3
Entrez ID		128178	10913
HPRD ID		05965	04974
Ensembl ID		ENSG00000186197	ENSG00000135960
Uniprot IDs		Q8WWZ3	Q9UNE0
PDB IDs
Enriched GO Terms of Interacting Partners?
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