SYT2 and KLHL3

Number of citations of the paper that reports this interaction (PubMedID 10734137)
26

Data Source:
HPRD (in vitro)

		SYT2	KLHL3
Description		synaptotagmin 2	kelch like family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Cell Junction Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Chromaffin Granule Membrane Exocytic Vesicle	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Inositol 1,3,4,5 Tetrakisphosphate Binding	Actin Binding Structural Molecule Activity Protein Binding
	Biological Process	Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Membrane Organization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Toxicity of botulinum toxin type B (BoNT/B) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Botulinum Toxin Type B
Diseases
GWAS		Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)	Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		5 interacting genes: KLHL3 NRXN1 STON2 SYNCRIP WNK1	16 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 WNK1 WNK3 WNK4
Entrez ID		127833	26249
HPRD ID		02520	09011
Ensembl ID		ENSG00000143858	ENSG00000146021
Uniprot IDs		Q8N9I0	Q9UH77
PDB IDs			4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?
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