COL1A2 and PDGFA

Number of citations of the paper that reports this interaction (PubMedID 8900172)
16

Data Source:
BioGRID (pull down)

		COL1A2	PDGFA
Description		collagen type I alpha 2 chain	platelet derived growth factor subunit A
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Platelet Alpha Granule Lumen
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein Binding, Bridging Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding Growth Factor Receptor Binding
	Biological Process	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Regulation Of Immune Response Leukocyte Migration Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly	MAPK Cascade Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Platelet Degranulation Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization	Non-integrin membrane-ECM interactions
Drugs		Collagenase clostridium histolyticum
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Osteogenesis imperfecta	Malignant pleural mesothelioma Glioma
GWAS		Aging ( 22773346) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Male-pattern baldness ( 28196072)
Interacting Genes		27 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SPARC TGFBI UBQLN1 VWF	14 interacting genes: A2M COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 PDAP1 PDGFRA SPARC
Entrez ID		1278	5154
HPRD ID		00363	01424
Ensembl ID		ENSG00000164692	ENSG00000197461
Uniprot IDs		A0A0S2Z3H5 P08123	P04085
PDB IDs		5CTD 5CTI 5CVA	3MJK
Enriched GO Terms of Interacting Partners?
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