ADH1A and HADH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ADH1A	HADH
Description		alcohol dehydrogenase 1A (class I), alpha polypeptide	hydroxyacyl-CoA dehydrogenase
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Alcohol Dehydrogenase Activity, Zinc-dependent Retinol Dehydrogenase Activity Protein Binding Zinc Ion Binding	3-hydroxyacyl-CoA Dehydrogenase Activity NAD+ Binding
	Biological Process	Alcohol Metabolic Process Ethanol Oxidation Drug Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process	Fatty Acid Beta-oxidation Response To Activity Response To Insulin Response To Drug Negative Regulation Of Insulin Secretion Positive Regulation Of Cold-induced Thermogenesis
Pathways		Abacavir metabolism RA biosynthesis pathway Ethanol oxidation	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs		NADH Fomepizole 4-Iodopyrazole N-Cyclopentyl-N-Cyclobutylformamide	NADH Acetoacetyl-CoA 3-Hydroxybutyryl-Coenzyme A
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 23456092) Regular attendance at a pub or social club ( 29970889) Urinary metabolite levels in chronic kidney disease ( 31959995)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		2 interacting genes: CSNK2A2 HADH	6 interacting genes: ADH1A APP CLK1 FBXO7 SLC2A4 STAT1
Entrez ID		124	3033
HPRD ID		00063	08372
Ensembl ID		ENSG00000187758	ENSG00000138796
Uniprot IDs		P07327	B3KTT6 Q16836
PDB IDs		1HSO 1U3T	1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS
Enriched GO Terms of Interacting Partners?
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