FSD2 and PPP2R5D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FSD2	PPP2R5D
Description		fibronectin type III and SPRY domain containing 2	protein phosphatase 2 regulatory subunit B'delta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Sarcoplasmic Reticulum Perinuclear Region Of Cytoplasm	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process		Protein Dephosphorylation Signal Transduction Nervous System Development Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Tourette syndrome ( 30818990)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		42 interacting genes: AQP1 BEX2 BEX3 BRD8 CBX8 CCDC112 CCHCR1 CDC73 CORO1A ESD FAM107A FAM161A FAM90A1 FMR1 IFT20 KANSL1 LATS1 LENG1 MRPL11 NDN PBX3 PIK3R3 POLL PPP1R18 PPP2R5D PSMB4 SH2D4A SPATC1L TCEANC TLE5 ZBTB38 ZC2HC1C ZMAT2 ZNF124 ZNF20 ZNF230 ZNF410 ZNF417 ZNF572 ZNF581 ZNF587 ZSCAN26	16 interacting genes: CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C RORC SGO1 USHBP1
Entrez ID		123722	5528
HPRD ID		17291	09039
Ensembl ID		ENSG00000186628	ENSG00000112640
Uniprot IDs		A1L4K1 B7ZM05	A0A024RD11 Q14738
PDB IDs
Enriched GO Terms of Interacting Partners?
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