CLK2 and RNPS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLK2	RNPS1
Description		CDC like kinase 2	RNA binding protein with serine rich domain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Response To Retinoic Acid Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription, DNA-templated RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		28 interacting genes: AKT1 CLK3 CPSF7 ECE1 GMCL1 KLHL2 LNX1 LUZP4 MRPL4 PRPF38A PTPN1 RBM39 RNPS1 RSRP1 SDCBP SRPK2 SRRM1 TRIM27 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF263 ZNF394 ZNF398 ZNF473 ZRSR2	34 interacting genes: CHERP CLK2 DVL2 GPATCH8 HEXIM2 HOXD4 LUC7L3 NKTR PIN1 PNN PRPF38A RBM8A SAP18 SART3 SDCBP2 SRP54 SRPK1 SRPK2 SRSF1 SRSF11 SRSF4 SRSF6 TAF2 TRA2B TRIM41 U2AF1 UBQLN4 UPF2 USP4 YWHAB YWHAG ZBTB14 ZNF473 ZNF490
Entrez ID		1196	10921
HPRD ID		04289	07341
Ensembl ID		ENSG00000176444	ENSG00000205937
Uniprot IDs		A8K7I0 B7Z8N6 P49760	D3DU92 H3BMS0 Q15287
PDB IDs		3NR9 5UNP 6FYI 6FYK 6FYL 6KHE	4A8X
Enriched GO Terms of Interacting Partners?
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