SSX2IP and CCNH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		SSX2IP	CCNH
Description		SSX family member 2 interacting protein	cyclin H
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Adherens Junction Cell Leading Edge Protein-containing Complex Centriolar Satellite Ciliary Basal Body	Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Transcription Factor TFIIK Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding DNA-dependent ATPase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Centrosome Cycle Cell Adhesion Regulation Of Rac Protein Signal Transduction Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Regulation Of Cell Motility	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS		Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 29875488) Diastolic blood pressure ( 27841878) Initial pursuit acceleration ( 29064472) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Prostate cancer aggressiveness ( 25939597) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		103 interacting genes: ABLIM3 ACTN1 ACTN2 AEN AFDN AP1M1 ARNT2 BCL6 BEX2 BRCA1 BYSL C11orf54 CARD9 CCDC198 CCHCR1 CCNH CDC23 CDC42 CDCA7L CHCHD3 DAXX DRG1 DVL2 EAF2 EHHADH EIF4A2 FAM124B FAM161A FAM214A FANCG FANCL FBF1 FNDC11 FRMD6 GEM GOLGA2 GOLGA8F GRAP2 HNRNPLL IKBKG INO80B KAT5 KDM1A KIF9 KLHL42 KRT15 KRT31 KRT40 KRTAP10-7 LATS1 LMO2 MCM7 MFAP1 MORN4 MOS MRPL53 NAA10 NDN NIF3L1 NOL12 NTAQ1 PHC2 PIMREG PKN1 PNMA1 POLL PRKAA1 PRKAB2 PRMT6 PRPF31 PSMA1 RNF6 SCNM1 SHFL SSX2 SSX3 SYT17 TBP TEAD4 TFIP11 TOP3B TRIM42 TRIM54 TSTD2 TTC23 WDR5 XIAP YWHAQ YWHAZ ZBTB24 ZFYVE26 ZGPAT ZMAT2 ZNF124 ZNF250 ZNF3 ZNF417 ZNF587 ZNF688 ZNF71 ZNF792 ZRSR2 ZSCAN12	35 interacting genes: AR CALCOCO2 CCDC170 CCDC33 CCNC CDK2 CDK20 CDK7 CDK8 CSNK2B CTBP2 DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GTF2E2 GTF2H1 KLC3 MCM7 MTA1 NDC80 NEDD4 POLR2A POLR2B PPFIA1 PSMA1 RARB SFN SSX2IP SUPT5H TP53 TRIM8 ZNRD2
Entrez ID		117178	902
HPRD ID		10566	09059
Ensembl ID		ENSG00000117155	ENSG00000134480
Uniprot IDs		B7ZB07 Q9Y2D8	P51946
PDB IDs			1JKW 1KXU 6O9L
Enriched GO Terms of Interacting Partners?
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