ADCYAP1 and ADCYAP1R1

Number of citations of the paper that reports this interaction (PubMedID 10583729)
27

Data Source:
HPRD (in vivo, in vitro)

		ADCYAP1	ADCYAP1R1
Description		adenylate cyclase activating polypeptide 1	ADCYAP receptor type I
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Neuron Projection Terminal Bouton Perikaryon	Cell Endosome Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Bicellular Tight Junction Cell Surface Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding Adenylate Cyclase Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding ADP-ribosylation Factor Binding Signaling Receptor Activity Neuropeptide Binding
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Insulin Secretion Neuron Projection Development Positive Regulation Of Interleukin-6 Production Regulation Of Protein Localization Negative Regulation Of GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II ATP Metabolic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Somatostatin Secretion Positive Regulation Of Blood Vessel Diameter Positive Regulation Of Cold-induced Thermogenesis	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Spermatogenesis Positive Regulation Of Calcium Ion Transport Into Cytosol CAMP-mediated Signaling Cell Differentiation Response To Estradiol Multicellular Organismal Response To Stress Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Development Of Primary Female Sexual Characteristics Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Cluster headache ( 27957625) Major depressive disorder ( 21621269) Non-word reading ( 30741946) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		8 interacting genes: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	3 interacting genes: ADCYAP1 CALM1 TMEM97
Entrez ID		116	117
HPRD ID		02369	00045
Ensembl ID		ENSG00000141433	ENSG00000078549
Uniprot IDs		B7Z222 P18509	A0A090N8F8 P41586
PDB IDs		1GEA 2D2P 2JOD	2JOD 3N94
Enriched GO Terms of Interacting Partners?
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