CHUK and TRAF2

Number of citations of the paper that reports this interaction (PubMedID 11359906)
36

Data Source:
HPRD (in vitro)

		CHUK	TRAF2
Description		component of inhibitor of nuclear factor kappa B kinase complex	TNF receptor associated factor 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Tumor Necrosis Factor Receptor Superfamily Complex Nucleoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex Plasma Membrane Receptor Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Scaffold Protein Binding Transferrin Receptor Binding	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein Binding, Bridging Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding Tumor Necrosis Factor Binding Protein-containing Complex Binding Sphingolipid Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Skeletal Muscle Contraction Protein Phosphorylation Inflammatory Response Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Rho Protein Signal Transduction Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Response To Acetate Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Reactive Oxygen Species TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Stress-activated MAPK Cascade Response To Cholecystokinin Interleukin-1-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Interferon-alpha Secretion	Positive Regulation Of T Cell Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Deubiquitination Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Cellular Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Immunoglobulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Death-inducing Signaling Complex Assembly Cellular Response To Nitric Oxide Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation
Drugs		Aminosalicylic Acid Mesalazine Sulfasalazine Acetylcysteine
Diseases		Cocoon syndrome
GWAS		Liver enzyme levels ( 18940312) Psoriasis ( 28537254) Type 2 diabetes ( 30054458)
Interacting Genes		81 interacting genes: AKT1 AKT2 AMBRA1 ATR BCL10 BCL3 BTRC CASP8 CDC37 CHEK1 COPS5 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 DCUN1D5 E2F4 EIF2AK2 ELP1 ERBIN ESR1 FKBP5 FOXO3 H3-4 H3C14 HSP90AA1 HSP90AB1 HTT IFIT5 IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP UBC UBE2E3 UBE2I UBE2N	258 interacting genes: AASDHPPT ABLIM1 ACTN3 AFF4 AIMP2 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 AXIN1 BAHD1 BANP BCL10 BECN1 BEX2 BEX3 BIRC2 BIRC3 CALCOCO2 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC198 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC42 CDCA3 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHMP2B CHUK CREB5 CRY1 CYB5R2 CYLD DGCR6 DLGAP5 DTNB DVL2 EDAR EDARADD EFEMP1 EFHC1 EGFR EIF4G1 ELOA2 ENKD1 EP300 ERN1 ETV6 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM90A1 FATE1 FBF1 FBXO28 FDXACB1 FLNA FNDC11 FNDC3B FXR2 GABPB1 GCKR GORASP2 GPKOW GSG1 GSTP1 HENMT1 HINFP HIVEP3 HOXA1 IKBKB IL15RA IPO11 IQUB IRF4 ITPK1 JUN KANSL1 KIAA0408 KIF26B KIFC3 KLF3 LINC02875 LNX1 LNX2 LRRK2 LTBR LZTS2 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MORN3 MPP3 MVP NATD1 NCAPH2 NEBL NECAP2 NFIL3 NGFR NIF3L1 NMUR2 NR2C2 NR4A1 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PCGF5 PDLIM7 PEG3 PGBD1 PIN1 PKN1 PPL PPP1R18 PRKAB2 PRKRIP1 PSME3IP1 PSMF1 QARS1 RAD23A RALBP1 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIPK1 RIPK2 RIPK3 RIPPLY1 RNF146 RRAS2 SETD5 SH2D4A SIAH2 SMG9 SMURF2 SNRNP25 SOX30 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCEA2 TCEANC TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TLE5 TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM31 TRIM37 TRIM42 TROAP TRPC4AP TRPT1 TSHZ3 TSSC4 UBC UBE2D1 UBE2D2 UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 VWA2 YES1 ZBTB16 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZMAT2 ZNF205 ZNF410 ZNF488 ZNF544 ZNF646 ZNF655 ZNF662 ZNF688 ZSCAN32
Entrez ID		1147	7186
HPRD ID		02811	03538
Ensembl ID		ENSG00000213341	ENSG00000127191
Uniprot IDs		O15111	A0A024R8H5 Q12933
PDB IDs		3BRT 5EBZ 5TQW 5TQX 5TQY	1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D
Enriched GO Terms of Interacting Partners?
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