GABARAP and FLCN

Number of citations of the paper that reports this interaction (PubMedID 25126726)
27

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		GABARAP	FLCN
Description		GABA type A receptor-associated protein	folliculin
Image
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Lysosome Autophagosome Smooth Endoplasmic Reticulum Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Actin Cytoskeleton Cytoplasmic Vesicle Cell Body Synapse Perinuclear Region Of Cytoplasm Sperm Midpiece	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cilium Midbody Cell-cell Contact Zone
	Molecular Function	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Protein Targeting Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Macroautophagy Autophagosome Maturation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Cellular Respiration Negative Regulation Of Mitochondrial DNA Metabolic Process Negative Regulation Of Muscle Tissue Development Negative Regulation Of Post-translational Protein Modification Positive Regulation Of TORC1 Signaling Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Macroautophagy TBC/RABGAPs	Amino acids regulate mTORC1
Drugs
Diseases			Renal cell carcinoma Birt-Hogg-Dube syndrome
GWAS			Heel bone mineral density ( 30598549)
Interacting Genes		51 interacting genes: AMBRA1 ANK2 ANK3 ATG101 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 BIRC6 CUL3 DMPK DVL2 FLCN GABRG1 GABRG2 GABRG3 GPHN HDAC5 KBTBD7 KDR LMNB1 MAPK15 MEFV MIB1 MLH1 MPC1 NBR1 NEDD4 NSF OPTN PCM1 PGS1 PKP4 RB1CC1 RETREG1 SQSTM1 SRPK1 SRPK2 TAX1BP1 TBC1D25 TFRC TLE5 TP53INP1 TRIM21 TUBB3 ULK1 ULK2 VPS28	4 interacting genes: APP GABARAP HSP90AA1 MAP1LC3B
Entrez ID		11337	201163
HPRD ID		05496	06278
Ensembl ID		ENSG00000170296	ENSG00000154803
Uniprot IDs		O95166 Q6IAW1	A0A0S2Z5Y7 Q8NFG4
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO	3V42 6NZD 6ULG
Enriched GO Terms of Interacting Partners?
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