ATXN2L and MPL

Number of citations of the paper that reports this interaction (PubMedID 11784712)
3

Data Source:
HPRD (in vivo)

		ATXN2L	MPL
Description		ataxin 2 like	MPL proto-oncogene, thrombopoietin receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Stress Granule Membrane Nuclear Speck	Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	Protein Binding Thrombopoietin Receptor Activity
	Biological Process	Regulation Of Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly	Neutrophil Homeostasis Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Platelet Aggregation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis
Pathways			Platelet Aggregation (Plug Formation)
Drugs			Romiplostim SB-559448 Eltrombopag
Diseases			Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29679657) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 28552196 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Crohn's disease ( 28067908) Educational attainment ( 25201988 23722424) Extremely high intelligence ( 29520040) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Pediatric autoimmune diseases ( 26301688) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		4 interacting genes: ATXN1 EPOR HADHA MPL	9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		11273	4352
HPRD ID		06394	01161
Ensembl ID		ENSG00000168488	ENSG00000117400
Uniprot IDs		H3BUF6 Q8WWM7	P40238
PDB IDs
Enriched GO Terms of Interacting Partners?
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