BIRC8 and UBE2V1

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (two hybrid)

		BIRC8	UBE2V1
Description		baculoviral IAP repeat containing 8	ubiquitin conjugating enzyme E2 V1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex Protein-containing Complex UBC13-UEV1A Complex Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Apoptotic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Canonical Wnt Signaling Pathway Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Activation Of MAPK Activity Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated JNK Cascade Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination
Pathways			NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: CASP9 FAM107A MAGED1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2K UBE2N UBE2V1 UBE2W	40 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN PSMD14 RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM25 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 XIAP ZNRF1
Entrez ID		112401	7335
HPRD ID		12525	04294
Ensembl ID		ENSG00000163098	ENSG00000244687
Uniprot IDs			G3V2F7 Q13404
PDB IDs			2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?
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