AKAP13 and PRKD1

Number of citations of the paper that reports this interaction (PubMedID 15383279)
67

Data Source:
BioGRID (pull down)

		AKAP13	PRKD1
Description		A-kinase anchoring protein 13	protein kinase D1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Actin Filament Cell Cortex Membrane Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm	Autophagosome Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane
	Molecular Function	CAMP-dependent Protein Kinase Activity MAP-kinase Scaffold Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Heart Development Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Cell Growth Involved In Cardiac Muscle Cell Development Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Glucocorticoid Mediated Signaling Pathway	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sphingolipid Biosynthetic Process Regulation Of Protein Stability Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Cellular Response To Hydroperoxide Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Central corneal thickness ( 31798171 29760442 20719862) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Idiopathic pulmonary fibrosis ( 29066090) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Psoriasis ( 25939698) Pulse pressure ( 30578418) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28552196 23669352 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) California verbal learning test score ( 31596458) Carotid plaque burden ( 28282560) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood body mass index ( 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) IgM levels ( 28628107) Intelligence (MTAG) ( 29326435) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656 30285260) Spatial processing ( 31596458) Systolic blood pressure ( 30224653) Type 2 diabetes ( 30130595) Urinary sodium excretion ( 31409800) Waist circumference ( 28552196 25673412) Weight ( 28552196)
Interacting Genes		22 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKACA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ	35 interacting genes: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 HDAC5 HDAC7 HSPB1 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A NOS1 PLCG1 PLCG2 PPP1R14A PRKCE PRKCH RACK1 SPRY2 SRC SYK TFAP2A TP53 USP28 YWHAQ YWHAZ
Entrez ID		11214	5587
HPRD ID		05253	05668
Ensembl ID		ENSG00000170776	ENSG00000184304
Uniprot IDs		A8MYJ1 B0AZU4 Q12802	F8WBA3 Q15139
PDB IDs		2DRN 2LG1 4D0N 4D0O 6BCA
Enriched GO Terms of Interacting Partners?
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